The Under-20 World Cup winner also makes his debut in the rivalry, with Alex Oxlade-Chamberlain and Andy Robertson getting their introduction to the feisty encounter as well.
Joe Gomez was named on the bench in the 1-1 draw in October 2015 but makes his maiden appearance in the fixture.
Jurgen Klopp has made six changes to the starting line-up from the 7-0 victory over Spartak Moscow as he continues his rotation policy during the hectic schedule.
#LFC starting XI v #EFC: Mignolet, Gomez, Lovren, Klavan, Robertson, Henderson, Milner, Oxlade-Chamberlain, Mane, Salah, Solanke— Melissa Reddy (@MelissaReddy_) December 10, 2017
Subs: Karius, Alexander-Arnold, Can, Wijnaldum, Coutinho, Firmino, Ings
Six changes to the XI. Daniel Sturridge is ruled out with a tight hamstring
Coutinho and Firmino are also on the bench after starring in midweek, while James Milner, who was brought on at left-back for the injured Alberto Moreno during that match, moves into the centre of the pitch.
Simon Mignolet switches in for Loris Karius in-between the sticks, while Danny Ings is added to a matchday squad for the second time this season - his last involvement was in the League Cup exit at Leicester City.
Daniel Sturridge misses out on derby day due to a tight hamstring.
Liverpool starting XI: Mignolet, Gomez, Lovren, Klavan, Robertson, Henderson, Milner, Oxlade-Chamberlain, Mane, Salah, Solanke
Liverpool subs: Karius, Alexander-Arnold, Can, Wijnaldum, Coutinho, Firmino, Ings
Everton starting XI: Pickford, Kenny, Martina, Holgate, Williams, Gueye, Davies, Sigurdsson, Rooney, Niasse, Calvert-Lewin
Everton subs: Robles, Schneiderlin, Keane, Jagielka, Lennon, Vlasic, Lookman