Adam Lallana was not included in the matchday squad at Stoke having suffered a slight knock and is unlikely to be involved on the weekend.
"It’s a minor muscle thing, nothing really serious but he needs a few days to recover from that and then he’s back in training and then in the squad," Klopp explained.
Ragnar Klavan was also excluded from the 18 due to illness, but he should be back in contention against Brighton.
Fellow centre-back Joel Matip, however, is ruled out. "After the game he had a problem, he felt something muscle-wise," the manager revealed.
"We have to make the final assessment, but it doesn’t look like he is available for tomorrow. That’s pretty much all.
"Klavan was ill but hopefully he is not anymore, especially when you think about Joel Matip’s situation. It’s not that we have a big choice to make in defence, so that’s the situation.
"We had a few knocks how it is after a game, and it is the shorter part of the week with Wednesday and Saturday. Not a long time to recover from different things. Final decisions will be made after the session at three o’clock."
Nathaniel Clyne remains a long-term absentee with a back injury.
Neither club have any suspension concerns for this game, but Emre Can is one caution away from a ban for the visitors, with Shane Duffy and Glenn Murray in the same danger for Brighton.
LIVERPOOL POTENTIAL STARTING LINE-UP
Klopp will continue to rotate during a stacked schedule as he looks to "bring the quality we have on the pitch with freshness. In this period you still need to have intensity in your game and you can have intensity every three days if you make the change, and that’s why we do it."
Philippe Coutinho, Jordan Henderson and Mohamed Salah were named as substitutes against Stoke and are likely to be restored to the XI.
Andy Robertson and Trent Alexander-Arnold will hope to fill the full-back positions with the impressive pair of Alberto Moreno and Joe Gomez due a rest.
The latter could fill in at the heart of defence should Klavan not be passed fit and with Matip missing.
BRIGHTON TEAM NEWS
Brighton are unbeaten at home since the first day of the season against Manchester City, but have drawn their last four matches on the south coast.
Chris Hughton's men will look to frustrate Liverpool with their obstructive approach. United struggled to break them down last weekend, with a heavily fortunate Lewis Dunk own goal seeing them record a 1-0 win.
The Seagulls have close to a fully-fit squad to select from, but Steve Sidwell remains out with a back injury, while Gaetan Bong has a knock.
Markus Suttner was drafted in for the latter in the 0-0 draw against Crystal Palace on Tuesday and was instrumental in Brighton keeping their fifth clean sheet of the season.
Goalkeeper Mathew Ryan turned in an inspired performance in midweek and will be looking to repeat that against an explosive attack on Saturday.
BEST OPTA MATCH FACTS
Liverpool have won just one of their last four Premier League away trips to newly-promoted sides (D1 L2), winning against Middlesbrough 3-0 in December 2016.
Only against Manchester City (17) have Chris Hughton’s sides conceded more goals than they have against Liverpool (15), though they’ve played twice the number of games against the Citizens (6).
Liverpool have now made 48 changes to their starting XI this season in the Premier League, 11 more than any other side (Everton next on 37).
TV COVERAGE & KICK-OFF TIME
Kick-off is at 3PM GMT (9AM CST) and the match won't be televised live in the UK.