The Reds had the previous weekend off as they were no longer in the FA Cup but they did come off with an impressive 2-0 win at Southampton before trashing FC Porto 5-0 in the Champions League last 16.
The Hammers equally had a previous free weekend but did claim a comfortable 2-0 victory over Watford a fortnight ago.
Things might have improved under David Moyes but they are just four points from the drop zone and a big win in a place like Anfield quoted at (12.00) will to ease off survival worries.
A stalemate at the end of 90 minutes is priced at (6.75).
The scoreline is a reflection of more than three goals surfacing in the clash which is available at odds of (1.45).
West Ham are surprisingly unbeaten in their last three visits to Anfield and are quoted at (2.70) to avoid losing.
David Moyes has never won in the red half of Merseyside but any chance of that happening can be backed with either team taking all three points at (1.08).
Three of the last five top-flight meetings between these sides has seen goal action at both ends of the pitch, including the reverse fixture at the London Stadium in November. It’s (1.90) for it to happen again.
Marko Arnautovic has had a hand in 10 league goals (seven goals, three assists) under Moyes’ charge. The Austrian is tipped to score anytime at (2.85).