Claude Puel's men booked their place in the last eight of the cup with a 1-0 win against Sheffield United last Friday, but it is league points that are at stake this weekend.
The Foxes will move into the Premier League's top seven for at least a few hours with a win in this one, and bet365 offer 8/11 (1.73) that they do just that.
Stoke face a scrap for survival and Paul Lambert's team can be backed at 4/1 (5.0) to take a significant step towards safety with a vital victory.
The same firm go 5/2 (3.50) that both sides settle for a share of the spoils.
Riyad Mahrez is in line for his first Premier League start for the Foxes since failing to secure a deadline day move to Manchester City.
Xherdan Shaqiri has scored in each of Stoke's last two matches and the Switzerland midfielder will be hoping to find the net in a third successive match.
Stoke's struggles on the road
The Potters have won just one away match in all competitions this season, losing seven of their last eight.
On top of that, Leicester have won four of their last five matches on their own patch and will be confident of further improving upon that record on Saturday afternoon.
Puel's men have conceded just one goal in five home matches in 2018 and they can be backed at 11/8 (2.38) with bet365 to keep a clean sheet against Lambert's side.
Tips and predictions
The Foxes have kept a clean sheet in six of their last seven home victories and bet365 offer 15/8 (2.88) that the trend continues when these two teams meet at King Power Stadium on Saturday afternoon.
Odds correct at time of writing. Please gamble responsibly.