Mark Hughes has overseen three consecutive league defeats since taking over last month, leaving his side five points adrift of safety with just five games left to play.
However, they are available at 11/5 (3.20) with bet365 to give their survival chances a much-needed boost by coming out on top in this one.
The Foxes ran out comfortable 4-1 winners when the sides met at St Mary’s in December’s reverse fixture, and are 5/4 (2.25) favourites to complete the double with another victory in front of their own fans.
Three of the hosts’ last four league matches on home turf have resulted in draws, and you can get odds of 23/10 (3.30) on them being forced to settle for a single point yet again.
Wilfred Ndidi is back from suspension, although Vicente Iborra, Daniel Amartey, Kasper Schmeichel and Matty James are all injury concerns.
Jack Stephens remains suspended after his red card against Arsenal, while Steven Davis faces a late fitness test.
Having struggled for cutting edge under Mauricio Pellegrino, the Saints have scored twice in three of their four matches since Hughes took over.
However, things seem to have come undone at the other end of the pitch, where they have conceded three times in each of the three league fixtures to come away with zero points.
This fragile backline is sure to be tested by Claude Puel’s team, who have only failed to score five times in 33 league games this campaign.
Nevertheless, having kept just once clean sheet in nine, Leicester should also have some difficulty in containing their guests’ newly prolific attack.
All in all, odds of 9/10 (1.90) are not to be missed on over 2.5 goals being scored for Southampton’s fifth consecutive league games, as well as the third encounter in a row between this pair.