As a result, bet365's latest Premier League odds have seen United pushed out to an industry best price of 25/1 (26.0) at the time of writing.
Jose Mourinho's side began the season at around 10/1 (11.0) to finish top of the table but their 2-1 win over Leicester did little to impress punters and bookmakers alike.
Unsurprisingly, City still head the betting at just 8/15 (1.53) having picked up six points from their opening two matches and scoring eight times in the process.
Despite an injury to Kevin De Bruyne, the Citizens swatted aside Huddersfield Town in a devastating display on their previous outing that would have delighted favourite backers.
Liverpool are the only other team available at a single figure quote. bet365 now make Jurgen Klopp's side a 3/1 (4.0) chance to record their first top flight crown since 1990. The Reds take on Crystal Palace on Monday night and are just 2/5 (1.40) to leave Selhurst Park with three points.
Chelsea (12/1) and Tottenham (14/1) come next in the betting but the bookmakers certainly seem to believe that the front two are some way clear of the rest according to the prices currently available.
United's disappointing defeat to Brighton has also seen them drift to 10/11 (1.91) to miss out on a top four spot and the result will only pile more pressure on Jose Mourinho.
The Portuguese has cut a frustrated figure throughout the last few months and things could get worse thanks to a tricky looking test up next.
Tottenham are 13/8 (2.63) to claim victory at Old Trafford ahead of next Monday's meeting between the top four rivals. United are also 13/8 (2.63) with the bookies struggling to split the sides, the draw is available at 9/4 (3.25).
Odds correct at the time of writing. Please gamble responsibly.