One of the leading candidates for the Premier League Golden Boot looks set for an extended spell on the sidelines.
Before that game got underway the England international was 9/4 (3.25) with bet365 to be the Premier League's leading marksman, tied with Mohamed Salah and Pierre-Emerick Aubameyang on 14 goals for the season.
The online bookmaker had already adjusted that to 11/2 (6.50) following Kane failing to score at Wembley and looking in some discomfort in the final stages of the match.
The news that he will miss a considerable proportion of the remaining season, though, has seen that price drift even further. Kane is now an industry-best 8/1 (9.0) with bet365 to finish top of the scoring charts this term.
The 25-year-old was crowned the top-flight's leading scorer in 2016 and 2017, only narrowly missing out on the prize in each of the other two campaigns where he was heavily involved.
Now though, even if Kane is back for Spurs' first game in March which comes against bitter rivals Arsenal, that will mean missing six league matches.
Although he has regularly found his most prolific form at the tail-end of seasons, Spurs’ main man will likely need to do so once again in order to be in the shake-up for a third Premier League Golden Boot prize.
What’s more, there's stiff competition from some of the division's other leading frontmen - two of whom sit joint-top of the standings with 14 goals apiece.
Mo Salah racked up 32 goals in an incredible first season back in England last term and the Liverpool striker is now 11/8 (2.38) favourite to retain the Golden Boot award. That price has been cut from 2/1 (3.0) following the news of Kane's injury.
The leading trio have a four-goal advantage over Sergio Aguero (13/2) and Eden Hazard (20/1) although it seems likely that Salah and Aubameyang will have further extended their lead by the time Kane is back in action.