In what is the Reds' curtain raiser for this year's International Champions Cup, Jurgen Klopp will be missing his star forwards - alongside Marko Grujic and the injured pair of Georginio Wijnaldum and Pedro Chirivella - when they trade tackles with the German outfit at the Bank of America Stadium.
Last season's 44-goal hero Salah and club's new no. 10 Mane, and Grujic only returned from World Cup holidays to join up with the rest of the squad on Friday morning.
And in the early hours of Saturday, Klopp's 29-man squad jetted out to North Carolina in time for a date against Lucien Favre's charges - who got their ICC campaign to a perfect start, having seen off Manchester City 1-0.
"Mohamed Salah, Sadio Mane and Marko Grujic will not be involved against the Bundesliga club having only returned to pre-season training on Friday," read a statement on club website.
The dynamic duo will watch the game from the sidelines but are likely to return for the last two games against Manchester City [in East Rutherford on Wednesday] and Manchester United [in Ann Arbor on Saturday].