The visitors have had a summer of uncertainty but have kept hold of key men James Chester and Jack Grealish, making them 4/1 (5.0) for promotion with SportPesa.
Hull, meanwhile, have a much younger squad this year and are 7/1 (8.0) outsiders to reach the top six.
The hosts are 37/20 (2.85) to begin with three points after last year’s brush with the drop.
Visiting boss Steve Bruce won two promotions with Hull and is 8/5 (2.60) to get one over his old club.
A draw, which occurred in both meetings between these sides last season including an opening day 1-1 stalemate, can be found at 11/5 (3.20).
Full-backs Eric Lichaj and Todd Kane could start for Hull, although the latter might be out of position on the left, while George Long, Jordy de Wijs and Reece Burke could also make competitive debuts.
Steve Bruce has been experimenting with a back-three in pre-season, but the shortage of centre-backs means Alan Hutton and Mile Jedinak may deputise there.
Ritchie De Laet is still suspended, so Ahmed Elmohamady should start.
Hourihane to strike?
Jonathan Kodjia is 37/20 (2.85) to score at any point, with the individualistic forward is set to lead the line and continue his fine form after hitting 19 league goals in two of his last three Championship seasons.
Alternatively, Conor Hourihane has been solid in pre-season, including netting a hat-trick at Walsall, and the Irishman is 9/2 (5.5) to hit the net anytime.
Preview and predictions
In 30 of Villa’s last 63 Championship encounters, they have avoided defeat in a game featuring two or fewer goals - whilst seven of their final eight games last term featured under three goals.
That record includes brushes with high-quality sides, whereas this match will be against a potentially less threatening Hull outfit. For that reason, the draw or away win with under 2.5 goals at 21/20 (2.05) our best bet.Draw or away win with Under 2.5 goals 21/20 (2.05) for a 1pt stake with SportPesa