Sunday afternoon sees Santiago Solari's side face Huesca for the first time ever, with the La Liga newcomers rooted to the bottom of the table.
Despite playing away from home, Real Madrid are the shortest priced team to win in La Liga this weekend. Los Blancos are offered at 3/10 (1.30) by bet365 to claim all three points.
Huesca's only league win of the campaign came back on the open weekend with the side picking up just seven points from a possible 42. They are 9/1 (10.00) on Sunday afternoon with the draw priced at 9/2 (5.50).
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Casemiro and Nacho Fernandez remain sidelined for the European champions while Toni Kroos and Marcelo are also likely to be unavailable.
Huesca, for their part, are without centre-back Ruben Semedo with full-back Luisinho also missing.
In their first ever top flight season, Huesca have so far been unable to keep a clean sheet. Indeed, the side from Aragon have the worst defensive record in La Liga having conceded 29 goals - although only eight of those have come at home.
Nevertheless, they could struggle against a Real Madrid side who have a point to prove after their disappointing showing in their last away league match.
Under Solari, Madrid have won seven of their eight matches and they should be backed to add another victory to that list.
Tips and predictions
Real Madrid to win by two goals or more is offered at 4/5 (1.80) and this looks like a strong angle from which to back the visitors.
Huesca are badly out of form, desperately low on confidence and begin the weekend seven points from safety. Real Madrid should be capable of dispatching their opponents this weekend without too many problems.
Odds correct at the time of writing. Please gamble responsibly.