These teams experienced contrasting fortunes in the Premier League last weekend, with Huddersfield hammering AFC Bournemouth 4-1 and Man United suffered a bitterly disappointing 1-0 defeat at Newcastle United.
The Terriers are bidding for a place in the last eight of the competition for the first time since 1972 - the last time that they competed in the top tier of English football.
Town claimed a famous 2-1 win against United the last time that they hosted Jose Mourinho's men and they can be backed at 7/1 (8.0) with dabblebet to grab another win.
However, the Red Devils eased to a 2-0 win when the teams met at Old Trafford earlier this month and dabblebet go 2/5 (1.40) that the visitors are victorious.
The same firm go 7/2 (4.50) that the match remains level after 90 minutes.
Alexis Sanchez scored his first Manchester United goal against the Terriers and the Chilean, who won this competition twice with Arsenal, will be determined to get amongst the goals again here.
With Premier League survival a priority for the Terriers, David Wagner is expected to shuffle his pack for this cup clash and a number of fringe players could feature.
United have yet to concede a goal in the FA Cup this season and Mourinho's side appear to be decent value at 17/20 (1.85) to keep the hosts at bay.
dabblebet also offer 21/20 (2.05) that there are fewer than three goals scored in the game.
Tips and predictions
Better value, though, lies in backing Manchester United to win to nil. The 21/20 (2.05) selection would have landed in each of the last six matches that Mourinho's team have won.