After returning to winning ways in midweek, the two giants failed to maintain the momentum on matchday seven.
The results have not only pushed them down the league table, but also shattered their hopes of tying leaders Ashgold at the top of the table.
On Saturday, Hearts were shocked by Elmina Sharks, who registered a 2-1 away win in Cape Coast. Felix Addo and Daniel Obeng Crentsil scored for Sharks, with the Phobians' consolation coming from Malik Akowuah. Hearts have dropped to sixth on the log, three places below Sharks.
Kotoko, on the other hand, suffered their first ever league defeat to Dreams FC on Sunday. The Porcupine Warriors could not hold their own in Dawu as George Dwubeng scored late to hand Still Believe a 1-0 victory. Paa Kwasi Fabin's men now sit seventh, with Dreams moving to fifth.
Medeama, however, did not miss the chance to tie Ashgold at the top as they secured a 1-0 win over eighth-placed Inter Allies in Saturday's other game. Joseph Tetteh Zutah scored the all-important goal in the 17th minute.
Ashgold did not have the opportunity to add three more points to their tally following the rescheduling of their tie with Aduana Stars. The latter have been excused from domestic action to concentrate on their upcoming Caf Confederation Cup clash with Malagasy outfit Fosa Juniors.
Elsewhere, Wafa suffered their fourth straight defeat of the campaign following a 2-1 loss to new boys Eleven Wonders at the Nana Ameyaw Park. Mohammed Alhassan's strike was overshadowed by goals from Yusif Hussein and Emmanuel Boahene. The Academy Boys have further fallen to the relegation zone as Wonders hold the ninth spot.
At the Golden City Park, Stephen Amankona's goal ensured a 1-0 home victory for Berekum Chelsea over tenth-positioned Bechem United. The Blues have consequently moved one place away from the drop zone.
It was a historic moment for debutants Karela United who registered their first away win of the topflight following a stunning 1-0 victory over 2015-16 champions Wa All Stars. United, who scored through Ibrahim Moro, and have thus joined the top four. The Northern Blues, meanwhile, sit bottom of the table.
Ebusua Dwarfs came from behind to snatch a 2-1 home win against 15th-placed Liberty Professionals. Benjamin Eshun opened the scoring for the visitors before Alhaji Mustapha and Dennis Korsah hit back for the Crabs.