Having run out 5-2 winners when the sides met in the quarter-finals of Euro 2016, they are 1/6 (1.17) favourites with William Hill to maintain the feelgood factor with another victory in Brittany.
In contrast, Erik Hamren's team have gone 11 matches without a victory and are 14/1 (15.00) outsiders to pull off a shock victory against the world champions.
The hosts were held to a 1-1 draw by the USA in their most recent friendly match back in June, and you can get odds of 13/2 (7.50) on them being forced to settle for another stalemate in this one.
Dimitri Payet has been drafted in to replace the injured Nabil Fekir, while Lyon youngster Tanguy Ndombele has received his first senior call-up. Mamadou Sakho, Kurt Zouma and Lucas Digne have all returned to the squad after lengthy absences.
Jon Dadi Bodvarsson and captain Aron Gunnarsson have both been ruled out through injury, with Albert Gudmundsson and debutant Jon Thorsteinsson called in to take their place.
Having punched above their weight impressively over the past few years, recent results have forced Strakarnir okkar to come back down to earth with a bang.
Although finishing bottom of a World Cup group that contained both Argentina and eventual finalists Croatia was certainly no disgrace, a winless run that stretches 11 games back over a year is a little more difficult to swallow.
Having conceded nine goals in just two UEFA Nations League games against Switzerland and Belgium, they must now take on a team that has put 27 goals past them in seven previous encounters on French soil.
With Didier Deschamps' men in high spirits, odds of 5/4 (2.25) offer solid value on their lethal frontline ensuring at least four goals are scored on the way to victory for their fourth consecutive meeting with Iceland.