The Ayew brothers have been out of the team since Ghana shared the spoils 1-1 with Congo in the 2018 Fifa World Cup qualifiers in Kumasi, missing the side's last four games.
Although, Appiah has revealed that he is using the opportunity to assess new players, reports in the local media suggest that he has closed the door on them after an alleged heated argument in camp.
“The perception that he [Appiah] has closed the doors on the Ayew brothers, I think that perception should also be worked on," Vanderpuye told Joy FM.
“Whether you like it or not, I can tell you for a fact that those boys are good. They are very good. Sometimes, the way to play them and how to play them is the problem, but I will never accept anybody who will try to convince me that somebody like Dede [and his brother] do not deserve to be in our team, he adds something to our team.
“Apart from his personal attributes, his tenacity in a game is very important. It inspires others, he fights. That is what we want," he added.