Wednesday's first leg takes place at Stamford Bridge and these two teams served up a Premier League classic just a week ago, drawing 2-2, so punters should be in for another entertaining encounter.
SportPesa have a huge offer for the game which is exclusive to Goal readers. Anyone yet to open an account with the online firm can take a huge price of 25/1 (was 4/6) on Chelsea securing an advantage for the return leg.
Simply register through the link provided, back the Blues and if they win then your returns will be topped up to the value of a 25/1 (26.0) winner. £1 max stake. Winnings paid in free bets. T&Cs apply.
The usual price of 4/6 (1.67) might seem a touch short on Chelsea against their London rivals but home advantage could be a huge factor given the respective sides' form in recent weeks.
Conte's side have won their previous four matches on this ground in all competitions, dispatching Stoke (5-0), Brighton (2-0), Bournemouth (2-1) and Southampton (1-0). Meanwhile, The Gunners have misfired away from the Emirates of late.
The dismal 4-2 defeat at Nottingham Forest in the FA Cup at the weekend was far from a one-off when it comes to disappointing away days for the Arsenal faithful. They've seen their side win just one of their last five games on the road overall courtesy of a 3-2 win against Crystal Palace.
In that run the visitors have drawn with Southampton, West Ham and West Brom. They'll certainly face a huge step up in quality of opposition here and with Arsene Wenger continuing to serve his three-match touchline ban, Chelsea will be keen to make this game count before heading to the Emirates for the second leg.
With the futures of Alexis Sanchez and Mesut Ozil still unclear as they approach the end of their respective contracts, Arsenal certainly don't look in great shape on or off the field.
Considering how strong Chelsea have been in front of their own fans recently, the exclusive 25/1 (26.0) for Goal readers should prove very popular ahead of this mouth-watering London derby so be sure to take it up if you want to cheer on the hosts at a massive price.