City hold a 16-point advantage over United with just eight games to play for both sides.
Depending on results this weekend, Pep Guardiola and Jose Mourinho will lock horns at the Etihad on April 7 in a tie which could hand the Catalan coach his first top-flight trophy in England.
Sam Allardyce's Everton are unbeaten at home since New Year's Day, however, and are the only Premier League team Guardiola has not beaten while in charge at City.
Will City take another step towards the title, or will the Toffees record their fourth consecutive home victory?
|Game||Everton vs Manchester City|
|Date||Saturday, March 31|
|Time||17:30 BST / 12:30 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBC Sports Live||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on BT Sport 1 and online via the BT Sport App.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport App|
Squads & Team News
|Goalkeepers||Pickford, Robles, Hewelt|
|Defenders||Keane, Williams, Jagielka, Mangala, Martina, Coleman, Holgate, Garbutt, Kenny, Feeney, Duke-McKenna|
|Midfielders||Schneiderlin, Gueye, Sigurdsson, Klaasen, Davies, Vlasic, Baningime, Denny, Lavery, Hornby, Collins, Gordon|
|Forwards||Bolasie, Rooney, Walcott, Tosun, Niasse, Calvert-Lewin, Broadhead|
Idrissa Gueye will undergo a late fitness test before the game but is likely to partner Wayne Rooney in midfield, with Theo Walcott and Yannick Bolasie operating on the wings.
Cenk Tosun has scored four goals in his previous three Premier League games and will continue as the focal point of the Everton attack on Saturday.
Potential Everton starting XI: Pickford; Coleman, Keane, Jagielka, Baines; Gueye, Rooney; Walcott, Davies, Bolasie; Tosun
|Position||Man City players|
|Goalkeepers||Bravo, Ederson, Grimshaw|
|Defenders||Walker, Danilo, Kompany, Stones, Laporte, Adarabioyo, Otamendi, Duhaney|
|Midfielders||Sterling, Gundogan, De Bruyne, Sane, B. Silva, D. Silva, Fernandinho, Zinchenko, Toure, Foden, Diaz, Dele-Bashiru|
|Forwards||Aguero, Nmecha, Jesus|
Sergio Aguero was not fit enough to play for Argentina during the international break and will give way to Gabriel Jesus in attack.
Fabian Delph has recovered from a knee injury and will play left-back against the Toffees.
Potential Man City starting XI: Ederson; Walker, Kompany, Otamendi, Delph; De Bruyne, Fernandinho, Silva; Sterling, Jesus, Sane
Betting & Match Odds
City are heavy favourites to win the game at Goodison, with dabblebet offering odds of 8/1 for an Everton victory.
An away win is priced at 4/11 and a draw 4/1.
Everton have won six of their last nine home games against Man City in all competitions and remain the only Premier League team to have come away from the Etihad with something to show from it.
The Toffees opened the season with a 1-1 draw in the reverse fixture, with Wayne Rooney and Raheem Sterling scoring the goals.
Should City win the game, however, they would become only the third team to beat all other teams in a single Premier League season, after Chelsea in 2005-06 and Manchester United in 2010-11.
City go into the weekend with a 16-point lead over second-placed Man United, with manager Pep Guardiola currently on 49 top-flight wins from his 68 games in the competition and on the verge of becoming the second quickest manager to reach 50 wins in the Premier League, after Jose Mourinho (63 games).
Everton have proved a thorn in Guardiola's side since arriving in Manchester, with the Toffees' 4-0 victory this fixture last season the Catalan's heaviest ever league defeat as a manager and one of just three occasions in his managerial career he has lost by four goals.
With that in mind, Guardiola and City will be keen to take revenge at Goodison Park this weekend and wmove a step closer to a Premier League crown.