Mark Hughes' men remain in the bottom three with just three matches remaining but, in beating Bournemouth, they have moved to within touching distance of their relegation rivals.
The Saints will hope to claim back-to-back Premier League wins for the first time this season when they travel to take on Sam Allardyce's Everton on Saturday evening.
Saints are chalked up as a 31/20 (2.55) chance with SportPesa to pick up three precious points on Merseyside, while the same firm offer 23/10 (3.30) that Hughes' charges settle for a share of the spoils against the Toffees.
Allardyce's outfit will be determined to win their final fixture of the campaign at Goodison Park and SportPesa go 39/20 (2.95) that the Toffees secure their 11th home win of the season.
James McCarthy, Eliaquim Mangala, Gylfi Sigurdsson, Maarten Stekelenburg, Mason Holgate and Dominic Calvert-Lewin are all out for the Toffees.
Southampton captain Steven Davis will miss out for the visitors.
Toffees to keep it tight?
Allardyce's side have conceded just one goal in their last four fixtures, while Saints have failed to find the net in three of their last four fixtures away from home in this competition.
SportPesa go 11/5 (3.20) that the Toffees keep a clean sheet, while the 33/10 (4.30) quote for Everton to win to nil could prove popular as it would have landed in three of the last four fixtures that the hosts have won.
Tips and predictions
Each of Everton's last seven goals at Goodison Park have come in the second half, while five of Saints' last seven away goals have been scored after the break.
The 20/21 (1.95) quote from SportPesa, then, for the second half to be the highest scoring half could well represent good value for punters ahead of Saturday's showdown.