The Toffees are unbeaten in four league matches against the runaway leaders, and have won six of the previous nine encounters on home turf.
However, they are hefty 41/4 (11.25) outsiders with SportPesa to extend that impressive run with another shock victory here.
Pep Guardiola's men were thrashed 4-0 when they visited this ground last season, but are clear 1/4 (1.25) favourites to exact revenge by coming out on top in this one.
Three of the most recent four league meetings between the sides have resulted in draws, and there are odds of 24/5 (5.80) available on them cancelling each other out once again.
Idrissa Gueye is a doubt after pulling out of the Senegal squad with an injury, while Gylfi Sigurdsson, Mason Holgate and James McCarthy are not fit. Meanwhile, Ashley Williams is suspended and Eliaquim Mangala is ineligible against his parent club.
Sergio Aguero faces a late fitness test after not featuring for Argentina, although Fabian Delph is hoping to return after missing the last month through suspension and injury.
With memories of that shock 4-0 defeat no doubt still fresh in the memory, the Citizens will be highly motivated when they take to the field on Merseyside.
Wednesday's Champions League clash against Liverpool will make City all the more determined to get this match shored up as quickly as possible - a challenge that looks well within their grasp on current form.
Having found the net prior to the break in 12 of their last 14 fixtures, odds of 71/100 (1.71) seem like solid value on City leading at both half-time and full-time against an Everton team that has only been on target in the opening 45 minutes in two of their previous 13 games.