The trip to Keepmoat Stadium will offer a stern test for the Premier League outfit as Grant McCann's men are unbeaten in 10 home matches in all competitions, and will certainly feel that they are capable of causing a cup upset.
Doncaster have reached the fifth round for the first time in 63 years and are available at 9/2 (5.50) to keep their FA Cup dream alive with victory inside 90 minutes.
Replays have been scrapped at this stage of the competition and, so, the tie will be played to a finish.
John Marquis, Doncaster's top scorer this term, will pose a significant threat to Palace. The 26-year-old has scored three goals in five matches in this competition thus far this term.
Roy Hodgson has insisted that this competition is not a priority. Wilfried Zaha is suspended but Scott Dann and Connor Wickham could both start. Michy Batshuayi could make his first start since joining the club on loan from Chelsea.
Home form key?
Doncaster have lost just two of their last 16 home matches in all competitions and McCann's side will hope to extend that impressive record. Rovers can be backed at 11/8 (2.38) to avoid defeat inside 90 minutes on Sunday.
A tight tussle?
Palace, though, have yet to concede a goal in the FA Cup this season. The Eagles are available at 6/4 (2.50) to win without conceding when they visit South Yorkshire on Sunday.
Palace, however, have found goals hard to come by this season and Doncaster could be well-placed to take advantage should Hodgson's men struggle to make their mark this weekend.
Rovers are available at 11/4 (3.75) with William Hill to qualify for the quarter-finals. That quote could well represent excellent value for punters ahead of this weekend's match.