Spurs have won six of their seven Premier League matches away from Wembley so far this season and Mauricio Pochettino's men are targeting a sixth successive away win in domestic competition.
Palace are without a win in their last six matches in all competitions and have failed to win any of their five fixtures on home soil this season, but a battling 2-2 draw against Arsenal in their most recent match at Selhurst Park will offer encouragement to the Eagles.
The odds compilers offer 11/4 (3.75) that both teams settle for a share of the spoils in south London - remarkably, just one of the 11 league meetings between these teams has ended in a draw.
Palace have no fresh concerns ahead of Spurs' visit, with Christian Benteke and Scott Dann both long-term absentees for the Eagles.
Mousa Dembele, Danny Rose, Eric Dier, Victor Wanyama and Jan Vertonghen are all out for Spurs.
History repeating itself?
Five of Spurs' last six wins against Palace have been by a 1-0 scoreline and 888Sport go 7/1 (8.0) that Pochettino's team win 1-0 in south London.
Indeed, nine of the last 11 matches between these teams have produced fewer than three goals and 888Sport go 21/20 (2.05) that the trend continues on this occasion.
Palace have failed to find the net in four of their five matches at home so far this season and they have managed just three goals in their last 10 league matches against Tottenham.
Spurs have maintained three clean sheets in their last five league matches and Pochettino's men could keep the out-of-sorts Eagles at bay at Selhurst Park on Saturday.
The 7/4 (2.75) quote from 888Sport, then, for Spurs to keep another clean sheet could provide punters with a path to profit this weekend.