It is the second meeting between the sides in the space of a week and, after coming out 3-2 winners at St Mary's last Saturday, the Blues will be aiming for a similar result.
Antonio Conte's side overcame Norwich, Newcastle United, Hull and Leicester to reach this stage and they have been forced into extra time twice already, a fate they will be eager to avoid at Wembley.
|Game||Chelsea vs Southampton|
|Date||Sunday, April 22|
|Time||15:00 BST / 10:00 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|FS1 / Fox Deportes||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 1 and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport app|
Squads & Team News
|Goalkeepers||Caballero, Courtois, Eduardo|
|Defenders||Rudiger, Alonso, Zappacosta, Cahill, Christensen, Azpilicueta, Luiz, Emerson, Ampadu, Sterling, Chalobah|
|Midfielders||Fabregas, Drinkwater, Kante, Barkley, Hazard, Pedro, Moses, Willian, Bakayoko, Scott, Hudson-Odoi|
Emerson featured on the left flank in place of the suspended Marcos Alonso against Burnley and is in line to reprise that role on Sunday with the Spaniard out. Concerns remain over the fitness and availability of Danny Drinkwater, David Luiz and Ethan Ampadu.
Potential Chelsea starting XI: Courtois; Christensen, Azpilicueta, Cahill; Emerson, Moses; Kante, Hazard, Willian; Giroud, Morata.
|Goalkeepers||McCarthy, Taylor, Forster|
|Defenders||Soares, Yoshida, Stephens, Hoedt, Bertrand, Pied, Bednarek, McQueen|
|Midfielders||Davis, Tadic, Romeu, Ward-Prowse, Lemina, Boufal, Redmond, Hojbjerg, Sims, Hesketh|
|Forwards||Long, Carrillo, Austin, Gabbiadini, Obafemi|
Mark Hughes says that he has no fresh injury concerns ahead of the semi-final, but doubts remain over the availability of Mario Lemina and Sofiane Boufal. Jack Stephens is suspended.
Potential Southampton starting XI: McCarthy; Bertrand, Yoshida, Hoedt, Bednarek, Soares; Hojbjerg, Romeu, Tadic, Davis; Long.
Betting & Match Odds
Chelsea are heavy favourites to win at 1/2 , with Southampton's chances rated at 6/1. A draw in 90 minutes is a 10/3 bet.
Chelsea may have a slim chance of finishing in the top four in the Premier League, but they have a better opportunity in the FA Cup, where Southampton stand in their way for a place in the final.
However, the oldest competition in football - and England's most prestigious cup - offers them a shot at redemption and they can put a positive spin on the campaign by lifting the trophy.
"For sure we will try to reach the FA Cup final," Conte told BBC Sport ahead of the game.
"It won't be easy but we must be ready to fight. I saw a fantastic spirit [against Burnley]. We must continue this way."
Having already beaten the Saints last week - albeit only just - they have a mental edge over their opponents, but, as Conte notes, they cannot afford to rest on their laurels on Sunday.