The Argentina striker has scored 10 goals against the Blues in all competitions - his best return against any opposition apart from Newcastle.
Aguero's absence would be particularly good news for Maurizio Sarri's men as it would most likely mean a start for Gabriel Jesus, who has only one goal to his name in 12 league appearances this campaign.
The misfiring 21-year-old is priced at a lengthier 13/10 (2.30) to score his first league goal since mid August.
However, the Citizens are certainly not reliant on strikers for firepower, with Raheem Sterling matching Aguero's eight-goal tally in the league so far and looks a solid bet at 29/20 (2.45), regardless of who he has playing ahead of him in attack.
It's not quite the same story at the other end of the pitch, where the Blues have looked reliant on Eden Hazard for cutting edge at times this campaign.
However, the Belgium star scored the last of his seven league goals this campaign six games ago back in early October.
Chelsea’s goal-scoring problems have not been helped by the fact that neither Alvaro Morata nor Olivier Giroud have really established themselves as first choice frontmen.
Morata has drawn the most criticism despite scoring a respectable five league goals in 10 starts so far, while Giroud has just one goal to his name in 12 league appearances. Both are available at reasonably long 15/8 (2.88) odds to prove their worth by scoring against the champions.