The champions have won 13 and lost none of their opening 15 Premier League matches this season, making a second consecutive title look increasingly inevitable.
Having come out on top in both encounters with this opposition last season, they are 10/11 (1.91) favourites with bet365 to strengthen their case as champions in waiting by securing an impressive victory in West London.
Maurizio Sarri's side have slipped 10 points adrift of first place after taking just four points from the last available 12, but are available at 3/1 (4.00) to blow the title race open by coming out on top here.
None of the last eight meetings between this pair have resulted in draws, but you can get odds of 3/1 (4.00) on them cancelling each other out in this one.
The likes of Jorginho, David Luiz, Olivier Giroud and Pedro may return to the side after being rested in Wednesday's defeat to Wolves, with Victor Moses the only injury doubt.
Sergio Aguero, Kevin De Bruyne and Oleksandr Zinchenko will all face late fitness tests but are unlikely to feature, while Benjamin Mendy, Claudio Bravo, and Eliaquim Mangala remain long-term absentees.
City too strong
While those hoping for a genuine title race will have earmarked this fixture weeks ago as a potential banana skin for Pep Guardiola's men, recent results have made the result look less finely balanced.
Having remained unbeaten until the 13th matchday, the Blues have now lost two of their last three games and are starting to look over-reliant on an Eden Hazard who is not quite firing on all cylinders as he was at the beginning of the season.
In contrast, the Citizens continue to make winning look effortless even when they are without star men such as Aguero, De Bruyne or Sterling, whether due to injury or rotation.
Realistically, those 10/11 (1.91) odds offer rare value on City coming out on top for the fourth meeting in a row against Chelsea, extending their winning streak to eight in a row in the league.
Odds correct at the time of writing. Please gamble responsibly.