Antonio Conte's men are eight points off the top four after losing at home to Tottenham Hotspur last weekend, their fifth defeat in seven league fixtures.
However, having won eight and lost none of their last 11 home league fixtures against this opposition, they are 2/7 (1.29) favourites with dabblebet to return to winning ways here.
Two of the last four league meetings between these sides on this ground have resulted in draws, and there are odds of 9/2 (5.50) available on them cancelling each other out once again.
Thibaut Courtois, Pedro and Davide Zappacosta are all back in contention after missing out against Spurs through injury, while Ross Barkley is also nearing a return.
Michail Antonio has joined Pedro Obiang, James Collins, Winston Reid, and Andy Carroll on the sideslines after suffering a hamstring injury against Southampton.
Javier Hernandez and Manuel Lanzini have returned to full training and could feature here.
Strong Chelsea record
Although the Blues' recent performances have clearly been well below par, this could be partly explained by a difficult recent fixture list that has seen them take on Spurs and both Manchester clubs in their last four matches.
They are likely to have far more joy against a team they have regularly beaten at Stamford Bridge over the last few years, and who have lost each of their last four consecutive away matches.
In fact, David Moyes' team could be in for a heavy defeat after conceding 13 times in those four games, making odds of 4/5 (1.80) look like solid value on Chelsea coming out on top in a match that features over 2.5 goals.
That bet looks particularly safe as there have been at least three goals in eight of West Ham's previous nine away league games, as well as seven of their hosts' last eight in the Premier League.