Chelsea remain top of the league under Antonio Conte with Jurgen Klopp's Liverpool 10 points behind after a poor January.
The Blues were beaten by Tottenham Hotspur in the new year after a 13-game winning streak, but they recovered in the league against Hull City at Stamford Bridge.
The two teams had mixed experiences in the FA Cup recently, with Liverpool falling victim to a shock home defeat to Wolverhampton Wanderers as Chelsea hammered Brentford 4-0.
Antonio Conte's men could strike a fatal blow to Liverpool's title hopes on Tuesday, but they will be mindful of the fact that they lost 2-1 when the two sides met at Stamford Bridge earlier in the season.
Chelsea have a full complement of players available for their trip to Liverpool on transfer deadline day. Asmir Begovic and Branislav Ivanovic are doubts, however, as both receive offers to move ahead of the transfer deadline after the game.
Kenedy has joined up with Chelsea's first-team and Nathan Ake has been integrated back into the squad after impressing in his comeback against Brentford at the weekend.
Meanwhile, Charly Musonda and Ola Aina may still be loaned out ahead of deadline day but will continue with the first-team squad if they fail to find appropriate moves.
Conte confirmed the good health of his squad on Monday afternoon: "No [injuries], not until now. I hope not. After the training session, we'll know this situation."
John Terry was sent off in Chelsea's 4-1 win over Peterborough United and has served his one match suspension after it was upheld, despite an appeal from the west London club.
In 2017 the rules alter slightly regarding suspensions for an accumulation of yellow cards, with 10 bookings now being required to get a ban. Pedro and N'Golo Kante are the closest players to Chelsea's next suspension as they moved to six bookings picked up in league and cup competition.
CHELSEA POTENTIAL STARTING LINE-UP
Conte will return to his tried and tested line up against Liverpool, as he opts for balance, while other managers rotate. He has often cited this as being integral to Chelsea's success this season and he rested a number of key players against Brentford at the weekend.
Eden Hazard, N'Golo Kante and David Luiz are just some of the players who were afforded a full-game break as Chelsea won easily against their west London rivals.
Diego Costa was on the bench against Brentford, with Michy Batshuayi starting, and he will come back into the starting line up as he looks to strengthen his claim as the Premier League's top scorer.
LIVERPOOL TEAM NEWS
While Chelsea are faced with relatively few injury concerns, Liverpool have a swathe of problems as they hit a period of bad form. Nathaniel Clyne is a doubt, while Danny Ings is on the long-term injured list.
Sadio Mane flew home from the Africa Cup on Nations on Monday and may feature, while Adam Lallana will return to Liverpool's starting line up. The Reds have no players suspended for Chelsea's visit to Anfield.
TV COVERAGE & KICK-OFF TIME
In the UK, the game is on BT Sport 1 at 20:00 on Tuesday night.