The Belgium international moves to centre forward in Antonio Conte's side, with Willian and Pedro flanking him in a new-look attacking line-up.
There is no room for Michy Batshuayi, however, who remains on the bench in spite of Morata's withdrawal due to a back injury.
Cesc Fabregas is another Blues substitute, with N'Golo Kante and Tiemoue Bakayoko preferred by Conte in the middle.
Huddersfield: Lossl; Lowe, Schindler, Jorgensen, Smith; Ince, Mooy, Hogg, Williamson; Kachunga, Mounie.
Subs: Coleman, Crainie, Depoitre, Hadergjonaj, Quaner, Whitehead, Van La Parra.
Chelsea: Courtois; Azpilicueta, Christensen, Rudiger; Moses, Kante, Bakayoko, Alonso; Willian, Hazard, Pedro.
Subs: Caballero, Cahill, Ampadu, Drinkwater, Fabregas, Musonda, Batshuayi.