The former Everton midfielder has not featured from kick-off in a single Premier League game this season after battling a hamstring injury.
And with Alvaro Morata out and Olivier Giroud unregistered for Wednesday's game Eden Hazard and Pedro are tasked with leading the line against the Cherries.
There is good news for Conte on the injury front, however, as Thubaut Courtois returns from a recent absence to replace Willy Caballero between the posts.
Chelsea: Courtois, Azpilicueta, Christensen, Cahill (c), Zappacosta, Kante, Bakayoko, Alonso, Barkley, Hazard, Pedro.
Substitutes: Caballero, Rudiger, Ampadu, Drinkwater, Moses, Fabregas, Hudson-Odoi.
Bournemouth: Begovic; Francis, Cook, Ake, Daniels; Ibe, Gosling, Cook, Fraser; Stanislas; Wilson.
Substitutes: Boruc, Simpson, Surman, Arter, Pugh, King, Mousset.