Both sides were beaten in their opening league fixtures - against Bournemouth and Tottenham, respectively - and, so, these two teams will be targeting a first win of the campaign this weekend.
The Bluebirds are back in the top tier after four years away and dabblebet go 21/10 (3.10) that Cardiff send their supporters home happy by winning this one, while the same firm offer 21/10 (3.10) that both sides pick up their first point of the season.
Newcastle won just one of their final eight fixtures away from home in this competition last term, but Benitez's team will be desperate to get off the mark here and are slight 6/4 (2.50) favourites to take all three points.
Kenneth Zohore was a notable absentee for the Bluebirds in Bournemouth but may be fit to start against the Magpies, while Harry Arter is in line to make his Cardiff City debut after joining on loan from the Cherries.
Joselu started and scored against Spurs last week, but the Spanish striker faces stiff competition for a starting spot from Salomon Rondon, who enjoyed an impressive cameo from the substitutes' bench last Saturday.
Goals at a premium?
No team outside of the Premier League's top seven conceded fewer goals than Newcastle United last term, but the Magpies managed just 39 goals of their own in 38 Premier League matches.
Both teams will consider this fixture to be eminently winnable and, therefore, there is a potential for this match to be more open and entertaining than many may anticipate.
The even money (2.0) quote for dabblebet for exactly two or three goals to be scored, then, could represent real value for punters ahead of Saturday's match.