Sean Dyche’s men have pulled out of the bottom three in recent weeks after winning their last two consecutive league games, leaving themselves two points head of 18th-placed Southampton.
Unbeaten in 29 home matches against this opposition since a 2-0 defeat in April 1951, they are 7/5 (2.40) favourites with William Hill to move further away from the drop zone by coming out on top here.
However, the Cottagers ran out 4-2 winners in the reverse fixture back in August, and are priced at 11/5 (3.20) to earn a precious three points with another victory.
None of the hosts’ last 10 fixtures have resulted in a draw, but you can get odds of 21/10 (3.10) on them playing out a stalemate in this one.
Robbie Brady is suspended after his late red card at Huddersfield in the last league match, while Phil Bardsley and Aaron Lennon are both injured.
Andre-Frank Zambo Anguissa and Alfie Mawson are both still unfit, although Calum Chambers should return to the team after being ineligible to face parent club Arsenal last time out.
Having eased past Barnsley in the FA Cup last weekend to take their winning streak to three in a row in all competitions, the Clarets should come into this game in confident spirits.
In contrast, Claudio Ranieri’s team followed up a 4-1 hammering by Arsenal with a cup upset at home to League Two Oldham, so will hardly be feeling particularly optimistic of improving on an away record that is the worst in the division.
With just two points to their name from a possible 33 on the road this campaign, those 7/5 (2.40) odds seem generous on Fulham coming away with nothing against a Burnley side that has won three of their last four home matches.