Sean Dyche's side have failed to win any of their last seven matches in all competitions, but having come close to upsetting Jose Mourinho's men at Old Trafford last month, the Clarets will be confident that they can get their season back on track with a win in the reverse.
Burnley allowed a two-goal lead to slip from their grasp when these teams met in Manchester last month and Betfair Sportsbook offer 11/2 (6.50) that Dyche's side take all three points on this occasion - should the Clarets deliver, it will be their first victory of 2018.
Man United took full advantage of Manchester City's first domestic defeat of the season as they closed the gap at the top of the table to 12 points with a supremely comfortable 3-0 win against Stoke City on Monday night, and Mourinho will demand that his side maintain their perfect start to 2018 with a win in this one.
The loss of Stephen Ward has been a bitter blow for Burnley and the Republic of Ireland international looks set to sit out once again when Mourinho's team visit Turf Moor.
Zlatan Ibrahimovic and Michael Carrick are expected to be sidelined once again this weekend, although Mourinho was able to welcome Antonio Valencia back into his starting line-up against Stoke City and the Ecuadorean - who scored the opening goal against the Potters - is expected to wear the captain's armband again this weekend.
A low-scoring contest?
Nine of Burnley's 11 Premier League matches at Turf Moor so far this season have seen fewer than three goals scored, with goals scored at both ends in only two of those matches; Betfair Sportsbook offer 8/11 (1.73) that there are fewer than three goals on this occasion, while the same firm go 4/6 (1.67) that either side fails to find the net this weekend.
The case for clean sheets
The Clarets have kept a clean sheet in each of the five Premier League victories that they have chalked up on their own patch so far this season; Betfair Sportsbook offer a generous 4/1 (5.0) that Burnley keep United at bay, while the same firm go 9/1 (10.0) that Dyche's side win without conceding.
United have kept a clean sheet in each of their four fixtures since conceding twice against Burnley at Old Trafford back on Boxing Day and Betfair Sportsbook go 10/11 (1.91) that they keep another clean sheet on this occasion, while the 13/10 (2.30) quote from the same firm for Mourinho's charges to win without conceding could well prove popular with punters.
Tips and predictions
Burnley have failed to score in four of their last six Premier League matches and, having hit just 19 league goals so far this season - significantly fewer than any other team in the top half of the table - it is fair to suggest that Dyche's side are not where they are due to their free-scoring form in the final third of the pitch.
No side has conceded fewer Premier League goals than Manchester United so far this season and, so, it is Betfair Sportsbook's 13/10 (2.30) quote for Mourinho's men to win without conceding at Turf Moor that could represent real value for punters ahead of Saturday's showdown.