Sean Dyche's side needed extra time to see off Aberdeen in the previous round and the Clarets will be hoping for a more comfortable evening when Abdullah Avci's men travel to Turf Moor.
Burnley are chalked up as an 11/10 (2.10) chance with William Hill to get the victory that will ensure their place in the next round of the competition.
The same firm go 11/5 (3.20) that the match ends level after 90 minutes. A score draw, of course, would send the Clarets crashing out of the competition.
Istanbul beat Ludogorets on their travels in this competition last term but that is their only win in six away matches in this competition and so are chalked up as a 27/10 (3.70) chance to triumph inside 90 minutes at Turf Moor.
Gael Clichy and Emmanuel Adebayor are familiar to English football fans and men could line up for the visitors here, although the former is more likely to play than the latter as the striker was omitted from the squad last week.
Goals at a premium?
There have been fewer than three goals inside 90 minutes in each of Burnley's previous three matches in this competition thus far this term, while there have been no more than two goals scored in four of Istanbul's last five fixtures.
The Clarets know that an away goal could prove fatal to their Europa League dreams and, so, Dyche's team will be desperate to keep things tight; William Hill go 7/5 (2.40) that Burnley keep a clean sheet on their own patch.
Backing Burnley to claim the win that they need could represent best value, though, and it is William Hill's 11/10 (2.10) quote for the Clarets to come out on top that could put punters on a path to profit.