The Red Devils are the reigning champions and have been handed a tie against the only non-Premier League outfit left in the competition and they will be confident in their ability to progress.
As the fixture list intensifies over the festive period, there are likely to be some changes, but Jose Mourinho has said they will be minimal due to Bristol City's standing in the Championship.
|Game||Bristol City vs Manchester United|
|Date||Wednesday, December 20|
|Time||20:00 GMT / 15:00 ET|
TV CHANNEL & LIVE STREAM
In the United Kingdom (UK) the game is available to watch live on television on Sky Sports Football, as well as being available to stream live online using Sky Go.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport app|
In the United States (US), the game is not being shown live on television, but it can be watched online using WatchESPN. Alternatively, you can follow live updates on Goal.
|US TV channel||Online stream|
SQUADS & TEAM NEWS
|Position||Bristol City players|
|Goalkeepers||Fielding, Steele, Lucic|
|Defenders||Pisano, Bryan, Flint, Wright, Baker, Magnusson, Kelly, Vyner|
|Midfielders||Smith, Brownhill, Reid, Eliasson, Pack, O'Neil, Bakinson, Hegeler|
|Forwards||Diedhiou, Taylor, Engvall, Paterson, Duric|
Lee Johnson has indicated that he has no fresh injury concerns heading into the game, but City will be without Cauley Woodrow and Jonathan Leko, who are cup-tied.
Callum O'Dowda is out of action after undergoing surgery on an ankle problem.
Potential Bristol City starting XI: Fielding; Flint, Magnusson, Baker, Wright; Smith, Pack, Paterson, Bryan, Brownhill; Reid
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Smalling, Shaw, Blind, Tuanzebe, Rojo, Jones, Darmian|
|Midfielders||Pogba, Mata, Lingard, Mkhitaryan, Young, Herrera, Mitchell, McTominay|
|Forwards||Lukaku, Ibrahimovic, Rashford, Martial|
Jose Mourinho has hinted that out-of-favour midfielder Henrikh Mkhitaryan will start the game as he prepares to rotate his squad somewhat.
Nemanja Matic may sit out the match with an injury, but Paul Pogba is available for selection again having served a three-match ban. Antonio Valencia, meanwhile, picked up a hamstring injury and is unlikely to be risked, while Eric Bailly and Marouane Fellaini are also doubts.
Potential Man Utd starting XI: Romero; Shaw, Smalling, Rojo, Darmian; McTominay, Herrera, Pogba, Young, Mkhitaryan; Ibrahimovic.
BETTING & MATCH ODDS
Manchester United are 8/15 favourites to win according to dabblebet, with Bristol City priced at 11/2 to beat the Red Devils. A draw at Ashton Gate is considered a 16/5 bet.
Romelu Lukaku is 13/5 to score first, while Zlatan Ibrahimovic, who could potentially replace the Belgian in attack, is rated 3/1.
The EFL Cup was the first trophy Mourinho won after taking the reins at Old Trafford, but, while he will surely wish to defend it, other competitions take priority this season.
United's designs on league glory took a hammer-blow last week when they lost at home to Manchester City, but there is still intense pressure to ensure a top-four finish, with the likes of Chelsea, Liverpool and Arsenal not far behind.
The Portuguese has hinted that Mkhitaryan will play a part, while other fringe players such as Luke Shaw and Zlatan Ibrahimovic, as well as back-up goalkeeper Sergio Romero, may also come into contention for a starting place.
Bristol City are flying high in the Championship and manager Lee Johnson is focused on mounting a promotion charge, so he too, has suggested that he will include some youth players in his matchday squad.
Regardless, the Red Devils will have to be at their best to see off the Robins, who also have the home advantage.