They come up against a Brighton side who are fighting to preserve their place in the division and the two teams have already played out two close encounters this season.
The Red Devils could only win 1-0 when they met at Old Trafford back in November and they defeated Brighton 2-0 at the same venue in the FA Cup in March.
However, Brighton are at home on this occasion and they will be buoyed having already beaten Arsenal and drawn against Spurs at the Amex this season.
|Game||Manchester United vs Brighton|
|Date||Friday, May 4|
|Time||20:00 GMT / 15:00 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBC Universo / NBCSN||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Matic, McTominay, Gomes|
|Forwards||Martial, Rashford, Lukaku, Sanchez|
Romelu Lukaku will miss the game after sustaining an injury in last week's victory over Arsenal, while Sergio Romero remains on the sidelines as he recovers from a knee injury. However, Mourinho has confirmed that Eric Bailly will be available.
Potential Man Utd XI: De Gea; Valencia, Bailly, Smalling, Young; Pogba, Matic, Mata, Martial, Sanchez; Rashford.
|Goalkeepers||Ryan, Maenpaa, Krul|
|Defenders||Bruno, Bong, Hunemeier, Dunk, Duffy, Goldson, Schelotto, Rosenior, Suttner, Mateju|
|Midfielders||Stephens, Kayal, Skalak, Knockaert, Gross, Sidwell, March, Propper, Hutchinson, Molumby|
|Forwards||Baldock, Hemed, Ulloa, Murray, Izquierdo, Locadia, Connolly, Tilley|
Brighton welcome Davy Propper back from suspension, meaning that Chris Hughton may opt to change things in midfield. Long-term absentee Steve Sidwell is still injured.
Potential Brighton XI: Ryan; Bruno, Duffy, Dunk, Bong; Propper, Stephens, Gross, Knockaert, Izquierdo; Murray.
Betting & Match Odds
Man United are favourites to win at odds of 4/5 according to dabblebet, while home side Brighton are deemed a 7/2 bet. A draw is available at 5/2.
Having played out two tight games against the Seagulls already this season, Mourinho is keenly aware of the threat that they pose to his team and, while Hughton's men have not won in their last seven games in all competitions, he is expecting another tough test on Friday.
"I think they are a good team and they are capable of giving us a difficult match," the United boss told MUTV. "They are not desperate – I think their position is good enough. I don’t think they need more points to survive. They just need mathematical confirmation, but they survive very well all season."
Brighton can consider themselves somewhat unlucky to have come away from Old Trafford with nothing to show for their efforts back in November and, having already taken points from Arsenal and Tottenham at home, they will be desperate to do the same against United.
However, the Red Devils have enjoyed a good run of form lately - winning games against Man City, Tottenham and Arsenal - and they will be keen to carry that forward as they gear up for their FA Cup final clash against Chelsea later in May.