The Seagulls have picked up 10 points from their last four league matches on home soil and Chris Hughton's men will be determined to return to winning ways against the Blues after being beaten by Burnley at Turf Moor last time out.
Chelsea have lost their last two league games away from home, but Maurizio Sarri's side will surely have a spring in their step on the back of a stunning 2-0 win against Manchester City in west London.
The Seagulls have lost just four of their last 25 Premier League matches on home soil and Chris Hughton's men are a 27/4 (7.75) shot with SportPesa to beat the Blues, while the same firm go 33/10 (4.30) that this match ends all square.
Chelsea can be backed at 5/11 (1.45) with SportPesa to pick up all three points from this fixture.
Glenn Murray was only fit enough to come off the bench as a second half substitute last weekend, but the veteran striker should be available to start here.
Jose Izquierdo and Alireza Jahanbakhsh both face a race against time to be fit, while Shane Duffy is suspended for the Seagulls.
With progression to the last 32 of the competition already assured, Chelsea rested a raft of regulars for their Europa League tie on Thursday, but Sarri's side should be back to full strength here.
Brighton have scored in each of their seven home matches in this competition this term, while Chelsea have scored in six of their seven Premier League games on the road.
Furthermore, each of Chelsea's last five away matches in domestic competition have seen more than two goals scored.
Brighton have a fine home record but Sarri's side will be brimming with belief after beating Manchester City at Stamford Bridge last weekend.
SportPesa's 6/5 (2.20) quote, then, for Chelsea to win a match featuring at least three goals appeals.
The selection would have landed in each of the Blues' five away wins in domestic competition so far this season.