Chris Hughton's men enjoyed a thrilling 3-0 victory against West Ham United at London Stadium last time out and, with confidence coursing through their veins, the Seagulls will fancy their chances of securing bragging rights against the Saints.
Brighton are unbeaten in their last four fixtures at Amex Stadium and will be confident of extending that fine record against Mauricio Pellegrino's men; Hughton's team are available at a generous 21/10 (3.10) with bet365 to enjoy back-to-back wins for the first time this season.
Pellegrino's team have had a stuttering start to the season, but Southampton moved back above Brighton in the Premier League standings with a hard-fought 1-0 win against West Bromwich Albion at St Mary's on Saturday evening; bet365 go 13/10 (2.30) that the Saints extend their points advantage over the Seagulls with a win in this one, while the same firm go 9/4 (3.25) that the match ends all square.
There will be plenty of pride and passion on display at Amex Stadium, but goals may we prove to be at a premium, for there have been more than two goals scored in just one of the Seagulls' five matches on their own patch so far this season; Hughton's men have conceded just four home goals this term and they have kept a clean sheet at the end of 90 minutes in three of their last five fixtures in all competitions.
Southampton have scored more than a solitary goal in just one of their last eight matches, while there have been more than two goals scored in just two of those outings; bet365 go 8/15 (1.53) that there are fewer than three goals on this occasion, while the same firm offer 4/5 (1.80) that either team fails to find the target.
Brighton have conceded just two goals before half time so far this season, while there has been just one goal scored before the break in the five fixtures that Hughton's team have contested on home turf this term; the 6/4 (2.50) quote from bet365, therefore, for the first half of this contest to end goalless may well prove popular with punters, while the same firm go 5/6 (1.83) that no goal is scored before the 33rd minute - only three of the 19 goals scored in the Seagulls' Premier League games so far this season has arrived before the 33rd minute mark.
There have been fewer than three goals scored in six of Southampton's last eight matches and another tight tussle looks likely here; the 8/15 (1.53) quote from bet365 for fewer than three goals to be scored, however, is somewhat skinny and better value may lie in backing the Seagulls to take the spoils.
Hughton's side were outstanding against West Ham United last time out and backing Brighton at 21/10 (3.10) with bet365 to make home advantage count against Southampton on Sunday could prove profitable.