The Seagulls will have fond memories of the most recent meeting between the two teams, for Chris Hughton's charges enjoyed a 1-0 win at Amex Stadium back in May and secured their Premier League status in the process.
After suffering a dismal 2-0 defeat at the hands of Watford last weekend, Hughton will hope that the memory of that famous triumph inspires his side ahead of Sunday's renewal.
Manchester United, of course, brought up the curtain on the Premier League season with a 2-1 win against Leicester City at Old Trafford on Friday night.
Jose Mourinho will expect more of the same from his side here and bet365 go 8/11 (1.73) that United chalk up a second successive league win.
Brighton captain Bruno limped off against the Hornets last week and is a major doubt, although club record signing Alireza Jahanbakhsh and fellow summer signing Yves Bissouma could both feature from the start.
Romelu Lukaku could make his first start of the season for United, while Ashley Young is also back in contention for a place in the starting line-up after being named as a substitute against the Foxes.
Three meetings between these teams in all competitions last season produced just four goals and bet365 go 13/20 (1.65) that there are no more than two goals scored in this game.
The same firm go 3/4 (1.75) that either side fails to score - that particular play would have landed in each of the last five meetings between the clubs.
Brighton failed to record a single shot on target last weekend and Mourinho's men will fancy their chances of shutting out the shot-shy Seagulls.
The 11/10 (2.10) quote, therefore, for Manchester United to keep a clean sheet could represent good value for punters ahead of this match.
Odds correct at time of writing. Please gamble responsibly.