Manchester City have been runaway champions this season, but Jose Mourinho's men are closing in on their first top-three finish since Sir Alex Ferguson called time on his tenure at Old Trafford in 2012.
Indeed, Manchester United look well-placed to finish second behind Pep Guardiola's champions and victory here would see the Red Devils move within a point of guaranteeing the runners-up spot.
United are unbeaten in five fixtures away from home in all competitions and are chalked up as an 8/11 (1.73) chance with dabblebet to extend that run to six matches.
The same firm go 13/5 (3.60) that the Seagulls settle for a share of the spoils.
Sergio Romero is again absent for Manchester United, while striker Romelu Lukaku is sidelined after limping out of the win over Arsenal last weekend .
Davy Propper is available again after serving a suspension, meaning Chris Hughton has an almost full squad from which to choose, with only long-term absentees Izzy Brown and Steve Sidwell missing for the hosts.
Despite their recent dip in form, Brighton have been solid on home soil this season, losing just two of their last 12 matches on their own patch.
Furthermore, Brighton have scored in nine of their last 11 matches at this venue and dabblebet price both teams to score at 5/6 (1.83)
The online bookmaker also offers 13/5 (3.60) that the Seagulls score more than one goal against the men from Manchester.
Tips and predictions
Manchester United were 2-0 winners when these teams met in the FA Cup quarter finals in March, while Mourinho's side won 1-0 in the Premier League fixture between the teams at Old Trafford in November.
There could be value, then, in backing another narrow win for Mourinho's men and dabblebet's 11/4 (3.75) quote for United to win a match featuring fewer than three goals could represent good value for punters ahead of Friday's fixture on the south coast.