Argentina are going through a difficult period following a disappointing World Cup and Lionel Messi's indefinite leave of absence from the side means they cannot rely on his genius to get them out of tough situations
If Brazil play to their full capacity they have a chance of recording a famous win against La Albiceleste.
The odds reflect the current disparity between South America's most successful football nations.
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Brazil coach Tite is likely to make a number of changes to the side that beat Saudi Arabia 2-0 on Friday. The likes of Alisson, Danilo and Miranda are all likely to come back into the team, while Neymar, Gabriel Jesus and Philippe Coutinho should all start.
Argentina are without Lionel Messi and coach Lionel Scaloni is likely to opt for Mauro Icardi up front instead of Paulo Dybala.
The Brazil team set to take the field at King Abdullah Sports City in Jeddah looks set to be considerably stronger than that of their opponents.
It has been a year of disappointment and recrimination in terms of the Argentine national football team and Brazil will look to take advantage of that instability, with their settled group of extremely talented players.
Both sides have kept three clean sheets against relatively low-key opponents since the World Cup and this will be their first respective test since Russia.
Tips and predictions
The smart money should be going on backing Brazil who look superior to Argentina in practically every aspect. The price for them to win in 90 minutes is smaller than many might have expected but will still attract some attention.
Brazil to score in the first half at 4/5 (1.80) should also be considered, with this bet paying out in five of their last six friendlies this year.
Prices correct at time of writing. Please gamble responsibly.