Tony Mowbray's team enjoyed an impressive 2-0 win against Millwall at the weekend and Rovers will fancy their chances of winning this one.
Newcastle have failed to win any of their last six and Rafael Benitez's men slipped into the Premier League's bottom three on Saturday. Furthermore, they have not won any of their last 15 FA Cup clashes away from St James' Park.
Blackburn came within six minutes or so of victory in the original tie and are chalked up as a 29/20 (2.45) chance to get the better of their Premier League opponents this time around.
Jack Rodwell deputised for the injured Charlie Mulgrew at the heart of Rovers' defence on Saturday and could retain his place. Another former Sunderland player, Danny Graham, could lead the line despite dropping to the bench against Millwall.
Preserving a Premier League place is Benitez's priority for Newcastle so Joselu, Freddie Woodman and Isaac Hayden are amongst those likely to be handed rare starts.
Goals at a premium?
Newcastle have scored just one goal in their last seven FA Cup ties away from home and William Hill offer 9/5 (2.80) that the Magpies draw a blank against Blackburn.
The same firm go 8/13 (1.62) that there are fewer than three goals. That particular selection would have landed in five of Newcastle's last seven away matches in this competition.
The Magpies have a wretched record in this competition - particularly on their travels and face a crucial Premier League clash with Cardiff City on Saturday, which could prove to be a huge distraction for Newcastle.
Blackburn may be well-placed to take advantage of any lack of focus from the visitors and it is, therefore, William Hill's 29/20 (2.45) quote for a home win that could offer best value ahead of Tuesday's tussle at Ewood Park.