A Billy Sharp hat-trick saw the Blades leading 3-0 in the 82nd minute of the game at Villa Park but the hosts fought back to earn a point.
Despite that, with 30 points from 15 home games in the second tier - including wins in their last four at this ground - it's understandable to see 888Sport make Wednesday's hosts 19/20 (1.95) favourites.
Middlesbrough have been in fine form on the road themselves, having taken 27 points from their 15 away games in the Championship this term. It's 29/10 (3.90) that the visitors come out on top while a draw between the high-flying pair is 23/10 (3.30).
With both teams in solid form calling the match odds market with any certainty looks a tough prospect. Instead, siding with goals could be the path to profit for punters looking to get involved.
This selection might seem counter-intuitive given these sides rank in the top three for defence this season. Boro have leaked just 23 times with Sheffield United conceding 34 goals.
However, it's now been five league games since Middlesbrough kept a clean sheet and with Chris Wilder's men having scored freely this term, it's a tough ask for the visitors to keep the Blades at bay in front of their own fans.
Friday night's late rally from Villa demonstrated that Sheffield United can be vulnerable and while Tony Pulis' side aren't overly prolific, their recent run of scoring in six consecutive Championship games is reason enough to back them to contribute in the final third.
The quality of opposition has been good in that run too. Pulis has seen his team score against Leeds, West Brom, Derby and Birmingham - all of whom sit in the top eight of the table coming into the midweek round of fixtures.
With that in mind both teams to score looks overpriced at Evens (2.0) with 888Sport. This selection has paid out in Boro's previous five matches and both teams should be able to find the net at least once at Bramall Lane.