Zlatko Junuzovic gave the Austrian champions an early lead but two goals in the final half hour of the first leg means Ivan Leko's men have an advantage heading to the Red Bull Arena.
That loss at Jan Breydelstadion was the first defeat that Marco Rose's men have suffered in Europe this season. Their dominant domestic form, where they sit 14 points clear at the top of the Austrian Bundesliga after just 18 games, will mean the hosts are still confident of progressing.
Understandably, Salzburg are favourites to come out on top in front of their own fans in the second leg, priced at 13/25 (1.52) with 888Sport to win the game in 90 minutes.
After dropping into this competition from the Champions League, Brugge have proved capable of holding their own against some of Europe’s heavyweights in recent months.
Their last two group games saw Leko’s side hold Atletico Madrid to a 0-0 draw at home after leaving Dortmund with the same result on matchday five.
Despite those low-scoring results, a game with goals at both ends could be a selection worth considering at 10/13 (1.77) here. Not least because these sides look much more comfortable going forward than they do at the back.
This selection would have paid out in each of Brugge's previous five matches in all competitions. They’ve had the firepower to avoid defeat of late but their last clean sheet came on December 27 2018.
Salzburg meanwhile, have seen goals at both ends in five of their eight Europa League games this term and have the attacking ability to cause plenty of problems for the visitors.
At 10/13 (1.77) another game where both teams get on the scoresheet appears a solid selection.