Ukraine are a best price of 3/4 (1.75) to continue their impressive recent run. It's been over a year since Andriy Shevchenko's side lost a game on the international stage.
They're two from two in this competition so far including a victory in the reverse fixture between these sides in September, courtesy of a 93rd minute winner from Manchester City's Oleksandr Zinchenko.
Jaroslav Silhavy's visiting team are 4/1 (5.0) underdogs despite beating Slovakia and claiming their first Nations League victory in their previous outing.
The best bet though, looks to be backing goals, especially at the current prices. Both teams to score is 57/50 (2.14) with 888Sport and that is an appealing selection given the recent form.
Ukraine have kept just two clean sheets in their last eight games. That spell includes the 2-1 win over Czech Republic last month and given that the away side have seen this bet land in their last three outings, backing another open game looks the way to go for punters.
Those seeking a bigger price should consider Ukraine to win and both teams to score which is priced at 7/2 (4.50) and has been a regular winner as far as Shevchenko’s side are concerned.
This has paid out in four of the hosts' last five international victories and while Czech Republic have the attacking power to make their mark, it could well be in vein as it was in the last meeting between the teams.