Benfica, who top the Primeira Liga table on goal difference, are 13/10 (2.30) to win the first leg though. Frankfurt are available at 41/20 (3.05) to take an advantage into the second meeting with the draw a 5/2 (3.50) chance in Lisbon.
The visitors have been involved in plenty of high-scoring European encounters this season. Adi Hutter's men netted 17 times in the group stage, the joint-second highest tally behind Sevilla (18).
Over 2.5 goals is available at 9/10 (1.90) with 888Sport but the value here appears to be in opposing a blockbuster encounter.
Including qualifiers, seven of Benfica's 10 matches in that competition this season saw no more than two goals scored. What's more, the four Europa League clashes they've played since their exit have seen the Portuguese side concede just twice.
Frankfurt got the better of Inter 1-0 on aggregate in the last 16, a far cry from their free-scoring clashes in previous rounds and it would be no surprise if this first leg was a low-scoring affair too. Under 2.5 goals is 23/25 (1.92) with 888Sport and that looks worthy of consideration.
Both sides have important clashes to consider in the days following this first meeting. The hosts are involved in a bitter battle with Porto for domestic dominance while Frankfurt occupy the final Champions League spot in the Bundesliga table and meet struggling Augsburg on Sunday night.
The odds suggest this quarter-final is tough to call and opposing a goal-filled game at 23/25 (1.92) offers solid value ahead of Thursday night’s clash in Lisbon.