Spurs have suffered Wembley woes this season in European competition, but Mauricio Pochettino's men remain unbeaten in domestic competition at White Hart Lane - a sequence of results that now stretches to 16 matches.
The hosts proved to be far too strong for Stoke City last weekend, claiming a comfortable 4-0 home victory against Mark Hughes' men and Betfair Sportsbook offer just 13/20 (1.65) that the north Londoners further extend their impressive home record with three points against the Toffees.
Ronald Koeman's side, though, will come into this clash in confident mood, for Everton are unbeaten in their last nine matches in the Premier League; the odds compilers offer 24/5 (5.80) that the Toffees come out on top.
The same firm go 29/10 (3.90) that this match remains level at the end of 90 minutes; a play that may well prove popular, for it would have landed in three of Everton's last four fixtures away from Goodison Park, as well as in the previous meeting between these teams - a 1-1 draw on Merseyside on the opening day of the campaign.
Everton have kept a clean sheet in five of their last seven league games and Betfair Sportsbook go 5/1 (6.0) that the Toffees shut out Spurs, while the same firm offer 7/5 (2.40) that it is the hosts who keep a clean sheet - a selection that would have seen punters profit from six of Tottenham's last seven league games at White Hart Lane.
There is, though, plenty of potential for goals when this rivalry is renewed, for both teams can boast a striker bang in form. Harry Kane has hit 10 goals in his last seven domestic appearances for Spurs - including three hat-tricks - and the England striker can be backed at 3/4 (1.75) to add to that tally at any time this weekend.
Romelu Lukaku wrote his name into the record books last week with his 60th strike in the Premier League - equalling Duncan Ferguson's record haul for the Toffees in this competition. Betfair Sportsbook go 17/10 (2.70) that the 23-year-old Belgian international, who has scored eight goals in his last eight games, surpasses the Scot by scoring on Sunday.
These two teams are brimming with belief and, packed with quality in the final third, there is plenty to suggest that the match at White Hart Lane could be an exciting, explosive encounter.
Betfair Sportsbook go 9/5 (2.80) that more than three goals are scored when these sides meet and that particular play could be a solid selection here, for it would have paid dividends in four of Spurs' last five home games in all competitions.