This is a general 10/1 (11.0) chance with most other firms so those who want to back it would be advised to do so with bet365 given the extra juice in the current price.
While the Reds have a game in hand over their nearest rivals, that clash is against Manchester United this weekend and the bookmakers currently believe it is the holders - who also have a goal difference that is 10 superior to Jurgen Klopp's side - that are in pole position to retain their domestic crown.
As the online bookmaker don't offer a multiple bet of City to win in each of the four outright markets, this wager is available in Team Outright Wins which is found under the Outrights menu in their football section via desktop, mobile or app.
Their FA Cup victory against Newport County on Saturday night means City have secured their spot in the quarter-finals of that competition too. Having been paired with Swansea in the next round, their quadruple odds have been trimmed from 16/1 (17.0) to the current quote of 12/1 (13.0).
With several big names such as Liverpool, Tottenham and Arsenal already out of the running and another set to exit as Chelsea host Manchester United on Monday, the Citizens are just Even money (2.0) to lift the trophy on May 18.
Qualification for the next round is just 1/66 (1.02) with bet365 and although tougher tests await a side that have failed to produce in the latter stages of the competition in the past, the same firm still make them 3/1 (4.0) market principles for European glory.
While it's true that City have had some kind draws in the domestic cups this term, that almost certainly won't be the case in Europe with no notable exits ahead of the knockout rounds getting underway.
Sergio Aguero has hit a purple patch in front of goal - netting nine goals in his last six games - but the strength in depth that Guardiola can call upon means City are better equipped to target such a haul of silverware better than anyone else.
Further progress in one competition could distract from their prospects in another of course, but at 12/1 (13.0) the bookmakers aren't writing off the possibility of Guardiola overseeing a trophy-laden end to the campaign.