As such, Pep Guardiola can afford to field his strongest side against one of the lesser lights left in Europe's top club competition in FC Basel.
The Catalan coach will be further buoyed by Sergio Aguero's four-goal performance against Leicester at the weekend, with Gabriel Jesus still unavailable through injury.
Basel, currently second in the Swiss Super League, five points behind Young Boys, bounced back from a home defeat to Lugano with an away win at FC Thun on Saturday and will look to bring the game to visiting City at St. Jakob Park.
|Game||FC Basel vs Manchester City|
|Date||Tuesday, 13 February|
|Time||19:45 GMT / 14:45 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Fox Sports 2||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport||BT Sport app|
Squads & Team News
|Position||FC Basel players|
|Goalkeepers||Vaclik, Salvi, Vailati, Antonio|
|Defenders||Lacroix, Lang, Suchy, Balanta, Riveros, Petretta, Pacheco|
|Midfielders||Frei, Zuffi, Campo, Okafor, Stocker, Die, Elyounoussi, Manzambi, Bua, Xhaka, Calla|
|Forwards||Van Wolfswinkel, Oberlin, Ajeti, Pululu|
Raphael Wicky looks likely to be without defensive midfielder Luca Zuffi as the Switzerland international struggles with injury, while goalkeeper Germano Vailati remains a long-term absentee.
Potential Basel starting XI: Vaclik; Lang, Suchy, Balanta, Petretta; Xhaka, Die; Stocker, Elyounoussi, Bua; Van Wolfswinkel
|Position||Manchester City players|
|Defenders||Walker, Danilo, Kompany, Stones, Laporte, Mendy, Adarabioyo, Otamendi|
|Midfielders||Sterling, Gundogan, De Bruyne, Delph, Sane, B. Silva, D. Silva, Fernandinho, Zinchenko, Yaya Toure, Foden, Diaz|
|Forwards||Aguero, Jesus, Nmecha|
Gabriel Jesus (knee), Benjamin Mendy (knee) and Leroy Sane (ankle) will all miss Tuesday's clash.
David Silva is also a doubt after missing Saturday's match with Leicester due to a hip issue.
The return of John Stones gives Pep a selection headache at the centre of defence, while Phil Foden offers the coach an additional option in midfield.
Potential Manchester City starting XI: Ederson; Walker, Laporte, Otamendi, Danilo; De Bruyne, Fernandinho, Gundogan; B. Silva, Aguero, Sterling
Betting & Match Odds
As expected, Manchester City are firm favourites to emerge victorious in Tuesday's match-up, with dabblebet pricing the Citizens at 1/3 (1.33). A win for Basel is priced at 15/2 (8.50), while a draw comes in at 15/4 (4.75).
A surprising draw away to Burnley at the beginning of February remains the only recent hiccup in Man City's seemingly unstoppable charge to the Premier League title, with 16 points now separating Guardiola's charges from second-placed Manchester United.
Injuries to Gabriel Jesus and Leroy Sane have been well covered by Sergio Aguero and Bernardo Silva, with the former having scored four goals in City's 5-1 rout of Leicester at the weekend to give Basel real food for thought as they prepare to face the English champions-elect.
Given their opponents' routine dominance of possession in games, Basel will likely opt for a sole striker rather than two up top, with exciting youngsters Dimitri Oberlin and Albian Ajeti almost certain to make way for the more experienced Ricky van Wolfswinkel to spearhead the attack.
Old heads Marek Suchy and Serey Die will undoubtedly be looked at to provide calm amongst a fairly young squad, while Taulant Xhaka, brother of Arsenal's Granit, will be aiming to give a good account of himself against one of the strongest midfields in recent memory.