The last side to win a Champions League match at the Camp Nou were Bayern Munich in May 2013, and since then the Blaugrana have recorded 26 wins and two draws.
Barcelona are already through as group winners and they are priced at 11/10 (2.10) with bet365 to finish the group stages with a win.
With Barcelona already guaranteed top spot there will be a temptation for Ernesto Valverde to rest some players, with Lionel Messi potentially dropping to the bench. The Blaugrana have Samuel Umtiti, Sergio Roberto, Arthur and Rafinha all out injured.
Spurs for their part are waiting on the fitness of Erik Lamela who has missed the last couple of games, while Davinson Sanchez, Victor Wanyama and Mousa Dembele remain sidelined.
Given Barcelona's home record in the Champions League, it is extremely difficult to see Spurs getting the win which would guarantee their qualification.
In recent years Barca have gone into the final group game already qualified and still managed to win it, while Spurs' away record does not inspire too much confidence.
Tips and predictions
The price for a home win is surely too good to turn down, and there should be plenty of interest in taking a Barcelona victory at 11/10 (2.10).
Prices correct at the time of writing. Please gamble responsibly.