The Blaugrana have won 23 and drawn two of their last 25 Champions League games in their own stadium and the Dutch visitors on Tuesday night know they are in for a tough trip.
However, PSV travel to Spain in superb form having won five matches out of five in the Eredivisie this term, scoring 21 goals in the process.
888Sport offer a home win at just 1/10 (1.10) which is an understandably small price given Barca's European record at the Camp Nou.
PSV boss Mark Van Bommel fielded a strong lineup for the 7-0 weekend win over ADO Den Haag, although Mexican midfielder Erick Gutierrez will push for a start after impressing from the bench on his debut with an assist and a goal.
The Dutch arrive in Catalonia in exceptional scoring form, having scored 13 goals in their last two league games.
Their Champions League play-off win over BATE Borisov saw them triumph 6-2 on aggregate and despite Barcelona's excellent home record, PSV will feel they can at least score.
Barca have conceded the first goal in both of their last two La Liga matches and while they have come back to win both of those clashes, Valverde's side have been at times unconvincing this term.
Tips and predictions
The price of 27/25 (2.08) therefore for both teams to score looks unmissable, while bolder punters might be interested in the price of 6/1 (7.00) for Barca to concede over 1.5 goals as they did in their last home game to tiny Huesca.