Barca's front two have been far from prolific in Europe this season but they will be out to make amends with the visit of Antonio Conte's side
Barcelona boast La Liga's top two scorers in Lionel Messi and Luis Suarez, but both players have struggled to replicate their domestic goalscoring in the Champions League.
Messi has netted just four times in seven appearances, while Suarez has started all seven matches for the Blaugrana and failed to find the back of the net.
The Blues, meanwhile, will be hoping that their joint-top scorer in the competition Willian performs as well as he did in the first leg - when he hit the woodwork before scoring an excellent goal.
Messi the value pick
bet365 have Messi as the favourite to net at the Camp Nou at 8/15 (1.53), with the Argentine offered at 11/5 (3.20) in the first goalscorer market.
Suarez is just behind him at 4/6 (1.66) to score his first European goal this season and at 13/5 (3.60) to break the deadlock.
Elsewhere, Ousmane Dembele can be backed at 5/1 (6.0) to open the scoring, whilst Ivan Rakitic is a tempting 10/3 (4.33) in the anytime market for his second Champions Legaue goals of the campaign.
Hazard to strike?
Chelsea know that they have to score at the Camp Nou to have any chance of progressing, and even one goal may not be enough against a Barca side that has 59 goals in just 20 home matches this season.
Willian is priced at a healthy looking 4/1 (5.00) to add to his tally of three Champions League goals this term, while Eden Hazard has also netted three times in the competition and is offered at 3/1 (4.00) to score at anytime.
Perennial substitute Olivier Giroud is 11/1 (12.0) to strike last, with ex-Real Madrid striker Alvaro Morata can be backed at 3/1 (4.0) to add to his one career goal against Barca.
Prices correct at time of writing. Please gamble responsibly.
Messi to score first at 11/5 (3.20) with bet365 for a 1.5pt stake