Messi will be reduced to the role of spectator as Barca take on arch-rivals Real Madrid at Camp Nou on Sunday after suffering a fractured arm in last weekend's 4-2 win over Sevilla, an injury that will sideline him for up to three weeks.
Their underwhelming start to the season follows a transfer window in which Madrid allowed Cristiano Ronaldo to depart for Juventus and did not make a move to replace him.
Yet even without the winners of the last 10 Ballons d'Or on the field, Griezmann, who confirmed his decision to stay at Atletico amid interest from Barca in a documentary released on the eve of France's successful World Cup campaign, expects an enticing contest.
"It's going to be a beautiful game like all the Clasicos," he told ESPN .
"It's a shame that Messi isn't there for Barcelona, but they have the players to win. Madrid are in need of a win to move forwards.
"It will be beautiful to watch."